Radiography in Zambia has undergone numerous changes involving learning methods, curriculum, professional status and public expectations. As a result, there has been a gradual transition of radiography from a primarily knowledge-based profession to an evidence-based discipline, and the concept of clinical effectiveness has become increasingly important in healthcare delivery in recent years. Solwezi General Hospital is a public level 2 hospital serving a local population of over 200,000 people and receiving patients from across the rural North West Province of Zambia. The hospital faces several challenges such as; staff shortages, inadequate medical equipment and has one of the highest mortality rates in the country. One thing that comes across clearly in the quarterly clinical and performance review meetings is the need for evidence-based practice and the achievement of clinical effectiveness across all departments of this hospital. Therefore, this exposition focuses specifically on the radiology department of this hospital and addresses the mechanisms necessary to achieve clinical effectiveness. Clinical Effectiveness Graham (1996) describes clinical effectiveness as “the right people, doing the right thing, in the right way, in the right way”. right place, at the right time with the right outcome” (quoted in Bury and Mead 1998, p.27). The National Health Service Executive (NHS E 1996a) further defines it as the extent to which specific clinical interventions achieve their intended purpose when used for a particular patient or population. The definitions above indicate that the concept of clinical effectiveness involves making clinical decisions based on solid evidence of what is effective to ensure maximum he...... half of paper ......y, T., Mead, J. 1998. Evidence-based health care: a practical guide for therapists. Oxford: Butterworth Heinemann, p.272) McKibbon, K.A. 1998. Evidence-based practice. Medical Library Association Bulletin, 83(3) pp. 396-401.3) Muir, JAG 2007. Evidence-based health care: how to make health policy and management decisions. 2nd ed. Edinburgh: Churchill Livingstone.4) Director of the National Health Service. 1996. Promoting clinical effectiveness: a framework for action within and across the national health system. London: DOH5) Royal College of Nursing. 1996. Royal College of Nursing Clinical Effectiveness Initiative: A Strategic Framework. London: RCN6) The Evidence-Based Radiology Working Group. 2001. Evidence-based radiology: a new approach to the practice of radiology. [Online] Available at: http://www.radiology.rsna.org/content/220/3/566.full [Accessed January 5 2011].