In recent years, an increasing amount of research has contributed to the development of knowledge about phantom limb pain (PLP). In this research proposal I aim to test mirror therapy as an effective treatment in PLP. Phantom limb pain occurs in at least 90% of limb amputees. PLP may be stimulated by the disconnection between visual feedback and proprioceptive representations of the amputated limb. Therefore, I will research both the neurobiology underlying this phenomenon and whether illusions and/or images of amputated limb movement (mirror therapy) are effective in relieving lower extremity PLP. Mirror therapy has been used with considerable success in patients who have undergone upper body amputations, but has not been established in lower extremity amputations. I would like to identify whether the form of treatment is equally effective in lower limb amputations. However, to consider mirror therapy as an effective means of treatment, it is necessary to understand PLP in its entirety. The main concern is if a limb is no longer attached to the body, how can neurons in the limb carry signals to the nervous system for the body to detect sensations? The biological significance of this project is to determine what happens at a sensory level to cause PLP. Once we discover this, we can evaluate whether or not mirror therapy is a plausible form of treatment. Context: Sensation, as we know it, is believed to be the result of direct contact between the body and an internal or external stimulus. However, in the case of the phantom limb phenomenon, the sensation is explained rather differently. The phantom limb phenomenon, in short, occurs when a person with a missing limb still feels like the limb is there; is having the perception of missing limbs and feeling sensations from i... middle of paper... can be determined, then steps can be taken to effectively treat PLP. A person studying another animal communication system would find this research important and interesting since most animals have similar neurobiological systems. Therefore, you can check whether this theory is also true for your own organism. If so, it is possible to develop mechanism-based treatments specific to PLP. Further research can also be performed to explain the relationship between the different proposed mechanisms listed above. Their results can be used to develop a universal hypothesis that explains PLP; this will become essential in the future for the evolution of therapeutic recommendations based on more specific mechanisms. These questions were chosen because my research aims to address the exact mechanism that causes PLP (neurobiology) and which treatment method is best for a given mechanism.