The first neural induction in amphibian embryos earned Hans Spemann the Nobel Prize in Medicine in 1935 for his paper “Spemann-Mangold Organizer”. The discovery with his student Hilde Mangold leads to the creation of a neuroectodermal primordium from which the nervous system arises involving the induction of chemicals such as fibroblast growth factor (FGF) and WNT signaling, along with the inhibition of signaling of bone morphogenetic protein-4 (BMP) activity to promote neuron development. Spemann's study succeeded in identifying a morphologically distinct cluster of mesodermal cells located in the dorsal lip of the blastophore known as the "organizer" that has the potential for neural induction. BMPs will activate neural induction and form during gastrulation in the vertebrate embryo which is secreted by the ventral gastrula signaling center (Spermann H, Mangold H, 1924). In a normal mechanism BMP binds to the receptor on the ectoderm cell to form the epidermis. However, by inhibiting BMP, ectoderm cells will differentiate to form neuron cells without the presence of neural inducers t...