On September 14, 1990, an operation called gene therapy was successfully performed at the US National Institutes of Health. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes into target cells and replaces defective genes to treat diseases that cannot be treated with traditional medicines. Although gene therapy gives those born with a genetic disease or those suffering from cancer a lifelong chance of being cured, it is high risk and sometimes unethical because the failure rate is extremely high and issues such as the use of “coupon ” and the “bad” of gene therapy has not yet been answered satisfactorily. Gene therapy offers people suffering from genetic diseases the chance to lead a normal life. Dangerous diseases such as AIDS, SCID, thalassemia and ADA can be successfully treated. On September 5, 2006, two people with advanced melanoma received gene therapy and soon recovered. This is a breakthrough in cancer gene therapy. Gene therapy uses patients' own cells to cure diseases and, therefore, no rejection in their bodies. Furthermore, patients could achieve a permanent cure from gene therapy without relapses. Despite being magical, gene therapy is high risk. Few people have benefited from it and it has a low success rate. Prior to human testing, Batshaw and Wilson had conducted experiments on animals to ensure their safety. Over 20 experiments were conducted on mice, but in the end only 12 of them survived (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases may arise during the treatment period, which can be more dangerous than genetic diseases. In December 200...... half of the document ...... of gene therapy it turns out that the mortality rate is very high. This is because the immune system can attack cells and cells can attack vital organs. Furthermore, ethical issues should be addressed in a positive manner. The technological institute must reduce unnecessary expenses of treatment. I strongly advise the government to invest more money in the development of gene therapy. To conclude, although gene therapy can cure a wide variety of diseases that cannot be cured with traditional medicine, and although patients can achieve a permanent cure without rejection, it can be highly risky and unethical. The negative effects of gene therapy have led to a reduction in the number of volunteers and many studies have been forced to cease. The potential for gene therapy to revolutionize medicine in the future is exciting and there is great hope for its role in treating and preventing childhood diseases.